Well Referenced

Tag: astrocytes

Progesterone suppresses Aβ-induced neuroinflammation by enhancing autophagy in astrocytes

This study investigates the neuroprotective effects of progesterone (PG) against amyloid-beta (Aβ42)-induced neuroinflammation in astrocytes. The findings reveal that Aβ42 impairs autophagic processes in astrocytes, leading to increased inflammatory responses. Treatment with PG significantly enhances autophagy activation, as evidenced by upregulation of autophagy markers and modulation of the mTOR signaling

Read More »
June 26, 2025 No Comments

Involvement of inflammation in Alzheimer’s disease pathogenesis and therapeutic potential of anti-inflammatory agents

This review explores the role of neuroinflammation in Alzheimer’s disease (AD) and the potential therapeutic application of anti-inflammatory agents. It highlights how astrocytes, microglia, peripheral immune cells, and microRNAs contribute to neuroinflammatory responses that exacerbate AD progression. Anti-inflammatory drugs may offer neuroprotection by modulating these pathways, potentially slowing disease progression

Read More »
June 26, 2025 No Comments