This study explores the cytotoxic effects of artesunate on retinoblastoma cells, revealing that artesunate selectively induces cell death through interaction with CD71, the transferrin receptor. The findings show that artesunate specifically targets retinoblastoma cells by exploiting the high expression of CD71, offering a novel mechanism for treating this aggressive pediatric
This study investigates the effect of artesunate on bladder cancer cells, showing that it induces apoptosis through the regulation of miR-16, which in turn downregulates the expression of COX-2, an enzyme associated with cancer cell survival and inflammation. The findings suggest that artesunate could be a promising therapeutic agent for
This study explores the mechanism by which artesunate induces G2/M cell cycle arrest in breast cancer cells. The findings show that artesunate triggers autophagy, which contributes to the arrest of the cell cycle at the G2/M phase. This process inhibits cancer cell proliferation and may enhance the effectiveness of artesunate
This study examines how artesunate overcomes drug resistance in multiple myeloma cells by inducing mitochondrial stress and non-caspase-dependent apoptosis. The findings suggest that artesunate disrupts mitochondrial function, leading to cell death independent of the traditional caspase pathway. These results highlight artesunate as a potential therapeutic agent to bypass common mechanisms
