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Tag: arsenic trioxide

Adding ascorbic acid to arsenic trioxide produces limited benefit in patients with acute myeloid leukemia excluding acute promyelocytic leukemia

This phase II clinical trial evaluated the efficacy and safety of combining arsenic trioxide (ATO) with ascorbic acid (AA) in patients with acute myeloid leukemia (AML) excluding acute promyelocytic leukemia (APL). Eleven patients, including elderly individuals unfit for intensive chemotherapy, received intravenous ATO (0.25 mg/kg/day) and AA (1 g/day) for

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June 26, 2025 No Comments

Artesunate possesses anti-leukemia properties that can be enhanced by arsenic trioxide

This study investigates the anti-leukemia effects of artesunate, a drug traditionally used for malaria, and its potential synergy with arsenic trioxide. The research shows that artesunate inhibits leukemia cell proliferation and induces apoptosis. Furthermore, when combined with arsenic trioxide, artesunate’s therapeutic efficacy is significantly enhanced, making it a promising combination

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June 26, 2025 No Comments

Glutathione levels are associated with methotrexate resistance in acute lymphoblastic leukemia cell lines

This study explores how intracellular glutathione (GSH) levels contribute to methotrexate (MTX) resistance in acute lymphoblastic leukemia (ALL) cell lines. Using metabolomic and gene expression analysis across 13 ALL lines, researchers found elevated GSH levels were associated with MTX resistance, indicating a constitutive metabolic defense mechanism. Key genes involved in

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June 26, 2025 No Comments