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Tag: arsenic toxicity

Arsenic Toxicity: Molecular Targets and Therapeutic Agents

This in-depth review outlines the molecular pathways affected by arsenic toxicity and surveys both conventional and emerging therapeutic strategies. Arsenic exposure—primarily via contaminated water and food—induces oxidative stress, mitochondrial dysfunction, epigenetic alterations, and DNA damage, contributing to carcinogenesis, cardiovascular disorders, and neurotoxicity. The review highlights the use of chelating agents

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June 26, 2025 No Comments

Toxic Metals and Antioxidants: Part II. The Role of Antioxidants in Arsenic and Cadmium Toxicity

This comprehensive review explores the mechanisms by which arsenic and cadmium exert toxic effects, primarily through oxidative stress and interference with essential metal ions. The article highlights the role of antioxidants and thiol-containing compounds in mitigating these toxicities. Key antioxidants discussed include S-adenosylmethionine, lipoic acid, glutathione, selenium, zinc, N-acetylcysteine (NAC),

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June 26, 2025 No Comments

Arsenic induced oxidative stress and the role of antioxidant supplementation during chelation: a review

This review article discusses arsenic’s toxic effects, particularly how arsenic exposure induces oxidative stress and how chelation therapies, such as BAL, DMPS, and DMSA, are used to treat arsenic poisoning. It highlights that antioxidants can enhance the efficacy of chelation therapy by reducing oxidative damage and improving detoxification outcomes. The

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June 26, 2025 No Comments