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Tag: aromatase inhibitor

Reduced breast cancer incidence in women treated with subcutaneous testosterone, or testosterone with anastrozole: a prospective, observational study

This prospective, observational study evaluated breast cancer incidence in 1,268 women treated with subcutaneous testosterone (T) implants, either alone or in combination with the aromatase inhibitor anastrozole (T+A), over a 5-year interim period of a 10-year study. Participants received T or T+A for hormone deficiency symptoms. With a cumulative follow-up

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June 26, 2025 No Comments

Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men

This randomized, double-blind, placebo-controlled trial investigated the distinct roles of testosterone and estradiol in regulating body composition, muscle strength, and sexual function in men. Healthy men aged 20–50 underwent pharmacological suppression of endogenous gonadal steroids and received varying doses of testosterone gel, with or without an aromatase inhibitor to block

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June 26, 2025 No Comments

The Antioxidant and HDAC-Inhibitor α-Lipoic Acid: Is Synergistic with Exemestane in Estrogen Receptor-Positive Breast Cancer Cells

The in vitro study examined the synergistic effects of the aromatase inhibitor exemestane and the antioxidant/HDAC inhibitor α-lipoic acid on estrogen receptor-positive (ER+) breast cancer cells (MCF-7 and T47D). The combination treatment significantly reduced cell viability, promoted apoptosis, and modulated key apoptosis-related proteins, increasing p21, APAF-1, BIM, and FOXO1 while

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June 26, 2025 No Comments