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Tag: antioxidant enzymes

Ozone in Medicine: The Low-Dose Ozone Concept and Its Basic Biochemical Mechanisms of Action in Chronic Inflammatory Diseases

This 2021 review by Viebahn-Haensler and León Fernández explores the therapeutic potential of low-dose ozone therapy in managing chronic inflammatory diseases characterized by oxidative stress and immune dysregulation. The authors describe how ozone, administered in controlled low doses, acts as a bioregulator by forming “ozone peroxides” that mimic hydrogen peroxide’s

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June 26, 2025 No Comments

CaNa2EDTA chelation attenuates cell damage in workers exposed to lead–a pilot study

This 2015 pilot study investigated the effects of CaNa₂EDTA chelation therapy on oxidative and genotoxic damage in smelting factory workers with chronic lead exposure averaging 5.8 ± 1.2 years. Following a five-day CaNa₂EDTA regimen, significant reductions were observed in oxidative stress biomarkers, including normalized activities of antioxidant enzymes (Cu,Zn-SOD and

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June 26, 2025 No Comments

Serum antioxidative enzymes levels and oxidative stress products in age-related cataract patients

This case-control study assessed oxidative stress and antioxidant enzyme levels in 60 patients with age-related cataracts compared to 60 healthy controls. Results showed significantly reduced serum activities of key antioxidant enzymes—superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px)—in cataract patients. Concurrently, levels of oxidative stress markers such as malondialdehyde

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June 26, 2025 No Comments

Taurine ameliorates neurobehavioral, neurochemical and immunohistochemical changes in sporadic dementia of Alzheimer’s type (SDAT) caused by intracerebroventricular streptozotocin in rats

This preclinical study evaluated the neuroprotective effects of taurine in a rat model of sporadic Alzheimer’s disease induced by intracerebroventricular (ICV) injection of streptozotocin (STZ). Rats received a single bilateral ICV-STZ injection (3 mg/kg), leading to cognitive deficits, oxidative stress, and cholinergic dysfunction. Taurine was administered orally at 50 mg/kg

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June 26, 2025 No Comments

The role of glutathione reductase and related enzymes on cellular redox homoeostasis network

This systematic review examines the role of glutathione reductase (GR) in maintaining cellular redox homeostasis, focusing on its crucial function in regenerating reduced glutathione (GSH), a major antioxidant. The review highlights how GR, in combination with other antioxidant enzymes, regulates reactive oxygen species (ROS) and oxidative stress responses. Differences in

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June 26, 2025 No Comments