Do estradiol levels influence on the cognitive function during antidepressant treatments in post-menopausal women with major depressive disorder? A comparison with pre-menopausal women
This observational study examined the impact of estradiol (E2) levels on cognitive function during antidepressant treatment in 39 women with major depressive disorder (MDD), comparing pre-menopausal and post-menopausal groups. Over a 6-week period, cognitive function improved significantly across all participants (P=0.00001), but in post-menopausal women, higher E2 levels were strongly