Well Referenced

Tag: antidepressant augmentation

Does Thyroid Hormone Have a Role as Adjunctive Therapy in Depression?

This 1996 review by I.M. Jackson evaluates the evidence supporting the use of thyroid hormones—particularly triiodothyronine (T3)—as adjunctive therapy in depression. The review highlights that hypothyroidism is commonly associated with depressive symptoms and should be treated with levothyroxine (T4). T3 has been shown to accelerate or enhance the response to

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June 26, 2025 No Comments

Efficacy of off-label augmentation in unipolar depression: A systematic review of the evidence

This 2017 systematic review evaluated the efficacy of off-label augmentation strategies in unipolar depression by analyzing data from meta-analyses, randomized controlled trials, and case studies. The review identified five agents—modafinil, ketamine, pindolol, estrogen, and testosterone (in hormone-deficient patients)—with evidence supporting their clinical effectiveness when added to antidepressant regimens. Other agents

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June 26, 2025 No Comments