Well Referenced

Tag: anti-angiogenesis

Repurposed Itraconazole for Use in the Treatment of Malignancies as a Promising Therapeutic Strategy

This 2022 review evaluates itraconazole, a triazole antifungal, as a repurposed anticancer agent. Itraconazole demonstrates anti-tumor activity by inhibiting angiogenesis and multiple oncogenic signaling pathways, notably the Hedgehog pathway. Preclinical studies show its efficacy in various solid and hematological malignancies. Clinical trials have reported benefits in prostate, lung, and basal

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June 26, 2025 No Comments

Repurposing Drugs in Oncology (ReDO)—Itraconazole as an Anti-Cancer Agent

This 2015 ReDO project review highlights itraconazole’s potential as a repurposed anticancer agent. Itraconazole, a triazole antifungal, exhibits mechanisms relevant to oncology including inhibition of angiogenesis, suppression of the Hedgehog signaling pathway, and induction of autophagic growth arrest. Preclinical and clinical evidence supports its efficacy in prostate, non-small cell lung,

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June 26, 2025 No Comments