Comparison of Continuous and Intermittent Anorectic Therapy in Obesity
This 1968 randomized controlled trial assessed the efficacy of continuous versus intermittent anorectic therapy in 108 obese patients over 28 weeks. Participants were divided into three groups: continuous phentermine, intermittent phentermine (alternating with placebo), and continuous placebo. Both phentermine groups achieved significantly greater weight loss compared to placebo. Notably, the