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Tag: amyloid plaques

Insights into the Potential Role of Mercury in Alzheimer’s Disease

This review examines the neurotoxic potential of mercury (Hg) in the pathogenesis of Alzheimer’s disease (AD). Mercury exposure—from environmental sources like atmospheric emissions and dietary intake of methylmercury—is proposed to disrupt multiple neurotransmitter systems, including serotonin, dopamine, acetylcholine, and glutamate. Additionally, mercury interferes with critical biochemical pathways involving homocysteine, arachidonic

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June 26, 2025 No Comments

Chronic Rapamycin Restores Brain Vascular Integrity and Function Through NO Synthase Activation and Improves Memory in Symptomatic Mice Modeling Alzheimer’s Disease

This 2013 study investigated the effects of chronic rapamycin treatment in transgenic mice exhibiting Alzheimer’s-like symptoms. Administered after symptom onset, rapamycin significantly restored cerebral blood flow, increased vascular density, reduced amyloid plaque accumulation, and minimized microhemorrhages. These effects were mediated by activation of endothelial nitric oxide synthase (eNOS), enhancing nitric

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June 26, 2025 No Comments

Methylene blue and Alzheimer’s disease

This review discusses the potential of methylene blue (MB) as a therapeutic agent for Alzheimer’s disease (AD). MB has been shown to reduce amyloid plaque and neurofibrillary tangle formation, improve mitochondrial function, and modulate neurotransmitter systems, including cholinergic, serotonergic, and glutamatergic pathways. These combined effects suggest that MB could offer

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June 26, 2025 No Comments