Cytotoxic effects of high concentrations of sodium ascorbate on human myeloid cell lines
This 2015 study investigates the cytotoxic potential of pharmacologic doses of sodium ascorbate (vitamin C) on several human myeloid leukemia cell lines, including HL60, U937, NB4, NB4-R4 (retinoic acid-resistant), NB4/AsR (arsenic trioxide-resistant), and K562. Results showed that sodium ascorbate induced dose-dependent apoptosis with an LC50 around 3 mM, primarily through
June 26, 2025
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