This 2024 cohort study analyzed data from 32,995 U.S. adults (mean age 46.7 years; 50.1% women) from the NHANES 1999–2018 cycles to evaluate trends in Body Roundness Index (BRI) and its association with all-cause mortality. BRI, which incorporates waist circumference and height, increased from 4.80 to 5.62 over the study
This 2015 meta-analysis evaluated 15 randomized controlled trials involving 17,186 overweight or obese adults (mean age 52 years, 53% female) to assess the impact of intentional weight loss on all-cause mortality. Participants underwent lifestyle-based weight loss interventions over periods ranging from 18 months to 12.6 years, achieving an average weight
This 1999 study analyzed data from the Tecumseh Community Health Study and the Framingham Heart Study to investigate the independent effects of weight loss and fat loss on all-cause mortality. Findings revealed that weight loss was associated with an increased mortality rate, while fat loss correlated with a decreased mortality
This large-scale prospective study analyzed data from 13,946 adults in the NHANES III cohort (1988–1994) with up to 12 years of follow-up. It found that even blood lead levels below 0.48 μmol/L (10 μg/dL) were associated with increased all-cause and cardiovascular mortality. Participants in the highest tertile of blood lead
This 2017 analysis of the Women’s Health Initiative (WHI) randomized trials examined the long-term effects of menopausal hormone therapy (HT) on mortality. Among 27,347 postmenopausal women followed for a median of 18 years, neither estrogen-alone nor estrogen-plus-progestin therapy was associated with increased all-cause or cause-specific mortality, including deaths from cardiovascular
This study analyzed data from 3,482 adults in the NHANES III cohort to examine the association between blood lead levels and mortality. Findings indicated that higher blood lead concentrations were significantly associated with increased risks of all-cause mortality (OR 1.05; 95% CI 1.01–1.08), all cancer mortality (OR 1.07; 95% CI
This 2015 study analyzed data from up to 10 Health Survey for England cohorts to assess the relationship between alcohol consumption and all-cause mortality among adults aged 50 and above. The findings indicated that any protective effects of alcohol consumption were largely confined to women aged 65 and older, particularly
This 2014 prospective cohort study analyzed data from 55,137 adults aged 18–100 over a 15-year period to assess the impact of leisure-time running on mortality. Approximately 24% of participants reported running. Compared to non-runners, runners exhibited a 30% lower risk of all-cause mortality and a 45% lower risk of cardiovascular
This 2015 prospective cohort study from the Japan Collaborative Cohort (JACC) study, published in the Journal of Clinical Nutrition, followed 58,615 adults aged 40–79 over a median of 14.7 years to examine the impact of dietary magnesium intake on mortality outcomes. Participants in the highest quintile of magnesium intake had
This retrospective cohort study analyzed data from 46,864 individuals aged 75 and older without clinically recognized atherosclerotic cardiovascular disease (CVD) to evaluate the impact of statin therapy on primary prevention. Over a median follow-up of 5.6 years, statin use did not significantly reduce CVD events or all-cause mortality in those
