Tag: alcoholic liver disease

High-dose intravenous glutathione in man. Pharmacokinetics and effects on cyst(e)ine in plasma and urine

This randomized, double-blind, placebo-controlled trial evaluated the effects of intravenous glutathione in 30 patients with alcoholic liver disease (ALD). Patients treated with glutathione showed statistically significant improvements in liver enzyme levels—specifically reductions in GGT, AST, and ALT—indicating reduced liver inflammation and oxidative stress. The therapy was well-tolerated, with no significant

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Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium

This symposium summary discusses the roles of S-adenosylmethionine (SAMe), folate, and betaine in treating alcoholic liver disease (ALD), focusing on their biochemical functions and therapeutic potential. These compounds act as methyl donors essential for hepatic transmethylation reactions, impacting homocysteine metabolism and influencing gene expression related to liver health. Deficiencies in

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