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Tag: alcohol use disorder

Alcohol Use Disorders and Current Pharmacological Therapies: The Role of GABA(A) Receptors

This comprehensive review examines the involvement of GABA(A) receptors in the pathophysiology of alcohol use disorders (AUD) and evaluates current and emerging pharmacotherapies targeting these receptors. Chronic alcohol exposure leads to neuroadaptive changes in GABA(A) receptor subunit composition and function, contributing to tolerance, dependence, and withdrawal symptoms. Traditional treatments like

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June 26, 2025 No Comments

Serious adverse events reported in placebo randomised controlled trials of oral naltrexone: a systematic review and meta-analysis

This systematic review and meta-analysis evaluated the safety profile of oral naltrexone by analyzing serious adverse events (SAEs) reported in placebo-controlled randomized controlled trials (RCTs). A total of 89 RCTs involving 11,194 participants across various conditions—including alcohol use disorders, psychiatric disorders, impulse control disorders, obesity, Crohn’s disease, fibromyalgia, and cancer—were

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June 26, 2025 No Comments

Pregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment-seeking individuals with alcohol use disorder

This study examined the effects of pregnenolone (PREG) on autonomic nervous system responses to stress and alcohol-related cues in individuals with alcohol use disorder (AUD). Fifty-five treatment-seeking participants were randomized into placebo (n=21), 300 mg PREG (n=18), and 500 mg PREG (n=16) groups over an 8-week period. Guided imagery sessions

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June 26, 2025 No Comments