Protein tyrosine phosphatase receptor δ serves as the orexigenic asprosin receptor
This 2022 study identified protein tyrosine phosphatase receptor delta (PTPRD) as the neural receptor for asprosin, a fasting-induced hormone derived from white adipose tissue. Asprosin crosses the blood-brain barrier and binds to PTPRD on AgRP neurons in the hypothalamus, activating them to stimulate appetite. Genetic ablation of PTPRD in mice
June 26, 2025
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