Well Referenced

Tag: aging-related diseases

Resveratrol as a Calorie Restriction Mimetic: Therapeutic Implications

This review examines resveratrol’s potential as a calorie restriction (CR) mimetic, highlighting its effects on aging-related diseases such as type 2 diabetes, cardiovascular diseases, and cancer in preclinical models. Resveratrol’s mechanism involves the inhibition of cAMP phosphodiesterases (PDEs), particularly PDE4, leading to increased cAMP levels and activation of downstream pathways

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June 26, 2025 No Comments

Changes of telomere status with aging: An update

This 2016 review examines the relationship between telomere dynamics and aging. It highlights that most human somatic cells exhibit irreversible telomere shortening with age, which is associated with aging-related diseases such as cancer, diabetes, and cognitive disorders. The authors discuss various methods for measuring telomere length, including quantitative fluorescence in

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June 26, 2025 No Comments

Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases

This review explores the concept of adaptogens—herbal substances that enhance the body’s ability to adapt to stress and promote overall well-being—highlighting their effects on the neuroendocrine-immune system. Adaptogens show a biphasic dose-response, acting as mild stress-mimetics at low doses and having varying effects at higher doses. The review emphasizes the

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June 26, 2025 No Comments