This 2018 review by Snyder et al. summarizes findings from the Testosterone Trials (TTrials), a coordinated set of seven placebo-controlled, double-blind trials involving 788 men aged 65 and older with low testosterone levels. The trials assessed the effects of testosterone therapy on various health domains. Key findings include: increased sexual
This 2014 review summarizes findings from the European Male Ageing Study (EMAS), a multicenter observational study involving over 3,000 men aged 40–79 from eight European countries. EMAS identified late-onset hypogonadism (LOH) as a distinct syndrome defined by the presence of low testosterone levels and three specific sexual symptoms: reduced libido,
This review examines the role of testosterone in cognitive function and mobility in aging men, finding that declining testosterone levels do not predict cognitive decline, Alzheimer’s disease, or mobility impairments. Randomized trials indicate that testosterone therapy does not significantly improve cognition or physical performance in men with low or low-to-normal
This cohort study found that testosterone replacement therapy (TRT) did not increase the risk of major cardiovascular or cerebrovascular events in aging men with low testosterone levels. The study involved 8,809 men aged 50+ and suggests that TRT may be a safe treatment option. It improves overall health, mood, and
This randomized controlled trial investigated the effects of testosterone therapy on insulin sensitivity, oxidative metabolism, and body composition in aging men with type 2 diabetes already on metformin therapy. The results showed significant improvements in insulin sensitivity, lean body mass, and fat mass, with statistically significant changes (p
