Well Referenced

Tag: aging brain

Efficacy of CDP-choline in the Treatment of Senile Alterations in Memory

This study explored the impact of CDP-choline (citicoline) on age-related memory decline. The research indicated that aging may impair cognitive function due to decreased synthesis or increased breakdown of choline-containing phospholipids, essential for neuronal membrane integrity. Administration of CDP-choline was found to increase brain levels of phosphatidylcholine and related phospholipids,

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June 26, 2025 No Comments

Modifying roles of glutathione S-transferase polymorphisms on the association between cumulative lead exposure and cognitive function

This cohort study examined how genetic variations in glutathione S-transferase (GST) enzymes—specifically the GSTP1 Val105 and GSTM1 deletion polymorphisms—modify the relationship between cumulative lead exposure and cognitive function in older men from the Normative Aging Study. Using bone lead levels measured by K-shell X-ray fluorescence and Mini-Mental State Exam (MMSE)

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June 26, 2025 No Comments

Cognitive response to testosterone replacement added to intensive lifestyle intervention in older men with obesity and hypogonadism: prespecified secondary analyses of a randomized clinical trial

A randomized controlled trial published in the American Journal of Clinical Nutrition (PMID: 34375393) examined the effects of testosterone replacement therapy combined with intensive lifestyle intervention in older men with obesity and hypogonadism. The study included 83 participants who were randomly assigned to either a testosterone or placebo group for

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June 26, 2025 No Comments