Well Referenced

Tag: acute respiratory distress syndrome

Growth hormone-releasing hormone in endothelial inflammation

This review examines the potential therapeutic effects of growth hormone-releasing hormone (GHRH) antagonists in protecting against endothelial barrier dysfunction, particularly in conditions like sepsis and acute respiratory distress syndrome. Preclinical studies suggest that GHRH antagonists could improve vascular function and reduce inflammation, making them promising candidates for treating vascular-related pathologies.

Read More »
June 26, 2025 No Comments

Interleukin-6: obstacles to targeting a complex cytokine in critical illness

This 2021 review article published in The Lancet Respiratory Medicine (DOI: 10.1016/S2213-2600(21)00103-X) delves into the complex biology of interleukin-6 (IL-6), a cytokine with both pro- and anti-inflammatory roles, and its implications in critical illnesses such as sepsis, acute respiratory distress syndrome (ARDS), and severe COVID-19. The review highlights IL-6’s multiple

Read More »
June 26, 2025 No Comments

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

This meta-analysis of 25 studies encompassing 1,245 patients with severe or critical COVID-19 found that average interleukin-6 (IL-6) levels (36.7 pg/mL) were significantly lower than those observed in cytokine release syndrome (3,110.5 pg/mL), sepsis (983.6 pg/mL), and non-COVID-19 acute respiratory distress syndrome (460 pg/mL). These findings question the characterization of

Read More »
June 26, 2025 No Comments