Well Referenced

Tag: acute myeloid leukemia

Adding ascorbic acid to arsenic trioxide produces limited benefit in patients with acute myeloid leukemia excluding acute promyelocytic leukemia

This phase II clinical trial evaluated the efficacy and safety of combining arsenic trioxide (ATO) with ascorbic acid (AA) in patients with acute myeloid leukemia (AML) excluding acute promyelocytic leukemia (APL). Eleven patients, including elderly individuals unfit for intensive chemotherapy, received intravenous ATO (0.25 mg/kg/day) and AA (1 g/day) for

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June 26, 2025 No Comments

Antileukemic activity and cellular effects of the antimalarial agent artesunate in acute myeloid leukemia

This study investigates the antileukemic activity of artesunate, an antimalarial drug, in acute myeloid leukemia (AML). The results show that artesunate effectively inhibits AML cell proliferation and induces apoptosis through reactive oxygen species (ROS) generation and mitochondrial dysfunction. These findings suggest that artesunate may serve as a promising therapeutic agent

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June 26, 2025 No Comments

The potential role of the thymus in immunotherapies for acute myeloid leukemia

This 2023 review explores the significance of the thymus in shaping T-lymphocyte immunity and its implications for immunotherapeutic strategies in acute myeloid leukemia (AML). The thymus is crucial for generating a diverse T-cell repertoire during early life, but its function declines with age and disease, leading to impaired T-cell-mediated immunity.

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June 26, 2025 No Comments

Erectile response to vardenafil in men with a history of nonresponse to sildenafil: a time-from-dosing descriptive analysis

This observational study examined the presence of jumping translocations involving the long arms of chromosome 1 in patients with myeloid malignancies. These chromosomal rearrangements, characterized by the translocation of chromosome 1q segments to different recipient chromosomes within the same individual, contribute to genomic instability and are associated with an increased

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June 26, 2025 No Comments