Well Referenced

Tag: ACE Inhibitors

Hiding in Plain View: The Potential for Commonly Used Drugs to Reduce Breast Cancer Mortality

This 2012 review explores the potential of repurposing widely used non-oncology drugs to reduce breast cancer mortality. The authors analyze observational data indicating that medications like aspirin, statins, metformin, beta-blockers, ACE inhibitors, and digoxin may lower breast cancer-specific death rates by 25–50%. Proposed mechanisms include anti-inflammatory effects (aspirin), lipid-lowering and

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June 26, 2025 No Comments

Pharmacologic Options for the Treatment of Sarcopenia

This 2016 review outlines pharmacologic strategies for sarcopenia, characterized by loss of muscle mass and function. While resistance exercise, protein supplementation, and vitamin D remain foundational treatments, pharmacologic options are under investigation. High-dose testosterone can increase muscle mass and strength but carries risks such as cardiovascular events and prostate enlargement.

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June 26, 2025 No Comments

Hormone treatments in congestive heart failure

This review explores the role of various hormone therapies in managing congestive heart failure (CHF). It highlights the significance of neurohormonal systems in CHF pathophysiology and discusses treatments like the dual-acting drug valsartan/sacubitril, which shows promise alongside traditional medications such as beta-blockers, ACE inhibitors, ARBs, and mineralocorticoid receptor antagonists. Clinical

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June 26, 2025 No Comments

Koschei the Immortal and Anti-Aging Drugs

This 2014 review by Mikhail V. Blagosklonny draws parallels between the Slavic folklore figure Koschei the Immortal and modern anti-aging strategies. The article posits that Koschei’s lean and ageless appearance could be attributed to mechanisms similar to those activated by calorie restriction (CR) and pharmacological agents like rapamycin. CR is

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June 26, 2025 No Comments