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Tag: 8-OHdG

Serum antioxidative enzymes levels and oxidative stress products in age-related cataract patients

This case-control study assessed oxidative stress and antioxidant enzyme levels in 60 patients with age-related cataracts compared to 60 healthy controls. Results showed significantly reduced serum activities of key antioxidant enzymes—superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px)—in cataract patients. Concurrently, levels of oxidative stress markers such as malondialdehyde

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June 26, 2025 No Comments

8-Hydroxy-2-Deoxyguanosine Levels and Cardiovascular Disease: A Systematic Review and Meta-Analysis of the Literature

This meta-analysis examined the association between 8-hydroxy-2-deoxyguanosine (8-OHdG) levels and cardiovascular disease (CVD), analyzing 14 studies with 810 CVD patients and 1,106 controls. Results showed significantly higher 8-OHdG levels in CVD patients compared to controls (standard mean difference: 1.04, 95% CI: 0.61–1.47, p < 0.001), with elevated levels observed in

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June 26, 2025 No Comments

Detection of 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker of oxidative damage in peripheral leukocyte DNA by UHPLC-MS/MS

This study investigated the detection of 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker of oxidative DNA damage using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) in peripheral leukocyte DNA. Elevated 8-OHdG levels have been linked to various conditions, including cardiovascular diseases and metabolic disorders, making it a valuable marker for assessing oxidative stress.

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June 26, 2025 No Comments

Occupational and lifestyle factors and urinary 8-hydroxydeoxyguanosine

This observational study examined the impact of occupational and lifestyle factors on urinary 8-hydroxydeoxyguanosine (8-OHdG) levels, a biomarker of oxidative DNA damage. Findings indicated that individuals with specific occupational exposures to hazardous substances or certain lifestyle behaviors exhibited higher 8-OHdG concentrations, suggesting increased oxidative stress. Monitoring urinary 8-OHdG provides a

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June 26, 2025 No Comments

Effect of age, smoking and other lifestyle factors on urinary 7-methylguanine and 8-hydroxydeoxyguanosine

This observational study examined the effects of age, smoking, and other lifestyle factors on urinary levels of 7-methylguanine (m7G) and 8-hydroxydeoxyguanosine (8-OHdG), biomarkers of DNA methylation and oxidative DNA damage, respectively. Analyzing 215 healthy Japanese individuals, the study found that current smokers exhibited significantly higher urinary m7G levels (p <

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June 26, 2025 No Comments

Oxidative stress biomarkers and lifestyles in Japanese healthy people

This observational study investigated the relationship between lifestyle factors and oxidative stress biomarkers in 135 healthy Japanese adults aged 20 to 69 years. The findings showed that smokers had significantly higher urinary 8-hydroxydeoxyguanosine (8-OHdG) levels (p < 0.05), indicating increased oxidative DNA damage, while individuals who engaged in regular physical

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June 26, 2025 No Comments