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Tag: 5-Diiodothyronine

3,5-Diiodothyronine: A Novel Thyroid Hormone Metabolite and Potent Modulator of Energy Metabolism

This review explores the metabolic effects of 3,5-diiodo-L-thyronine (3,5-T2), an endogenous thyroid hormone metabolite. In rodent models, exogenous 3,5-T2 administration rapidly increases resting metabolic rate and induces beneficial hypolipidemic effects. The mechanisms are primarily non-genomic, targeting mitochondria to enhance oxidative phosphorylation and fatty acid oxidation. While some thyroid hormone receptor-mediated

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June 26, 2025 No Comments

Biological Effects of 3,5-Diiodothyronine (T₂)

This review explores the biological activities of 3,5-diiodothyronine (T₂), a metabolite of thyroid hormones. T₂ stimulates mitochondrial respiration through nuclear-independent pathways, enhancing energy expenditure and oxygen consumption. It influences mitochondrial functions, including oxidative phosphorylation and fatty acid oxidation, and modulates enzymes and ion transporters. T₂ also exhibits thyromimetic effects, impacting

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June 26, 2025 No Comments