In this 2023 review, Yaku and Nakagawa explore the role of NAD+ precursors, such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), in human health and disease. They discuss how NAD+ levels decline with age and in various diseases, and how supplementation with these precursors can restore NAD+ levels, potentially
This 2022 review by Nadeeshani et al. critically examines the potential of nicotinamide mononucleotide (NMN) as an anti-aging nutraceutical, highlighting both its therapeutic promises and safety considerations. NMN, a precursor to nicotinamide adenine dinucleotide (NAD+), plays a pivotal role in cellular metabolism, DNA repair, and mitochondrial function. Preclinical studies have
This 2010 review by Rothman et al. explores the rationale and potential benefits of using combination pharmacotherapy for obesity treatment. Recognizing that appetite and weight regulation involve multiple physiological pathways, the authors argue that targeting several mechanisms simultaneously may enhance weight loss outcomes. They discuss various drug combinations, including phentermine/topiramate
In this 2023 review published in The Journals of Gerontology: Series A, Freeberg et al. assess the current landscape of NAD+ precursor supplementation in humans, focusing on nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). The authors highlight that NAD+ levels decline with age and in various disease states, contributing to
This 2023 study by Lalosevic et al., published in Acta Dermato-Venereologica, investigated serum zinc levels in patients with alopecia areata (AA) compared to healthy controls. The study included 100 AA patients and 100 age- and sex-matched healthy individuals. Results showed that the mean serum zinc concentration was significantly lower in
This 2020 review article by Pecora et al., published in Nutrients, examines the critical roles of various micronutrients in modulating immune responses, particularly against respiratory viral infections. The authors highlight that deficiencies in vitamins A, C, D, E, B6, B12, folate, and trace elements like zinc, selenium, copper, and magnesium
This 2003 randomized, prospective, placebo-controlled study by Arda et al., published in Otology & Neurotology, investigated the efficacy of oral zinc supplementation in treating tinnitus. The study enrolled 41 patients with idiopathic tinnitus and no known ENT pathology; 28 received 50 mg/day of elemental zinc, and 13 received a placebo
This 2023 review article by Zou et al., published in Frontiers in Medicine, examines the multifaceted roles of zinc in skin health and its involvement in various dermatological conditions. Zinc is crucial for maintaining skin integrity, modulating inflammation, and supporting immune responses. The review discusses zinc’s involvement in skin disorders
This 2024 cross-sectional study, published in Cureus, investigated serum zinc levels in Kurdish adults experiencing hair loss. The study included 100 participants aged 18–60 years, divided into two groups: 50 individuals with clinically diagnosed hair loss and 50 age- and sex-matched healthy controls. Serum zinc concentrations were measured using atomic
This clinical trial investigated the effects of synthetic growth hormone-releasing factors (GRF1-44, GRF1-40, and GRF1-29) on growth hormone (GH) secretion in healthy adult males. The study demonstrated that all three GRF analogs significantly increased GH secretion, with GRF1-44 producing the most substantial response. The findings suggest that synthetic GRFs can
