Well Referenced

Category: Cancer & Oncology Support

Supportive and adjunctive therapies for cancer prevention and treatment.

Cancer incidence and mortality in women receiving estrogen and estrogen-progestin replacement therapy–long-term follow-up of a Swedish cohort

This study on hormone replacement therapy (HRT) in 22,597 Swedish women found that while HRT did not increase overall cancer mortality, it increased risks of breast and endometrial cancers, especially with estrogen-progestin therapy. However, HRT appeared to offer protection against colon and liver cancers. The findings suggest that the type

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June 26, 2025 No Comments

Cognitive effects of hormonal therapy in older adults

This review explores the effects of gonadal steroids on cognitive function and the impact of hormonal therapies in older adults, particularly those undergoing cancer treatment. It highlights potential cognitive risks associated with anti-estrogen and anti-androgen therapies while noting inconclusive clinical evidence on hormone replacement therapy’s neuroprotective benefits. Clinicians should weigh

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June 26, 2025 No Comments

Combined estrogen and progestin hormone replacement therapy in relation to risk of breast cancer in middle-aged women

This case-control study investigated the relationship between combined estrogen and progestin hormone replacement therapy (HRT) and breast cancer risk in middle-aged women. The study found no significant increase in breast cancer risk for women using HRT, with a potential reduction in risk for long-term users. These findings suggest that combined

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June 26, 2025 No Comments

Controversial issues in climacteric medicine II. Hormone replacement therapy and cancer. International Menopause Society Expert Workshop. 9-12 June 2001, Opera del Duomo, Pisa, Italy

The article titled “Controversial issues in climacteric medicine II. Hormone replacement therapy and cancer. International Menopause Society Expert Workshop. 9-12 June 2001, Opera del Duomo, Pisa, Italy” (PMID: 11588941) discusses the relationship between hormone replacement therapy (HRT) and cancer, based on expert discussions from the International Menopause Society. However, the

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June 26, 2025 No Comments

Current perspectives on benefits and risks of hormone replacement therapy

The review article “Current Perspectives on Benefits and Risks of Hormone Replacement Therapy” (2001) examines the effects of hormone replacement therapy (HRT) on postmenopausal women’s health, highlighting potential benefits and risks. Findings suggest that HRT users experience a 34% reduction in colorectal cancer risk and a 20% to 60% reduction

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June 26, 2025 No Comments

α-Lipoic acid sensitizes lung cancer cells to chemotherapeutic agents and anoikis via integrin β1/β3 downregulation

The study titled “α-Lipoic acid sensitizes lung cancer cells to chemotherapeutic agents and anoikis via integrin β1/β3 downregulation” (PMID: 27431988) explored the effects of α-lipoic acid (LA) on lung cancer cells. This in vitro study found that LA increased reactive oxygen species levels, leading to the downregulation of integrin β1

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June 26, 2025 No Comments

Major surgery diminishes systemic arginine availability and suppresses nitric oxide response to feeding in patients with early stage breast cancer

The study titled “Major surgery diminishes systemic arginine availability and suppresses nitric oxide response to feeding in patients with early-stage breast cancer” (PMID: 28826699), published in Clinical Nutrition in 2018, examined the impact of major surgery on arginine metabolism in early-stage breast cancer patients. This observational study found that surgery

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June 26, 2025 No Comments

Alpha lipoic acid inhibits proliferation and epithelial mesenchymal transition of thyroid cancer cells

This in vitro study investigated the effects of alpha-lipoic acid (ALA) on thyroid cancer cell proliferation, migration, and invasion. Using four human thyroid cancer cell lines (BCPAP, HTH-83, CAL-62, and FTC-133), researchers found that ALA significantly suppressed cancer cell proliferation by activating the AMPK pathway, leading to the downregulation of

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June 26, 2025 No Comments