Pentadecapeptide BPC 157 Counteracts L-NAME-Induced Catalepsy: BPC 157, L-NAME, L-Arginine, NO-Relation, in the Suited Rat Acute and Chronic Models Resembling ‘Positive-Like’ Symptoms of Schizophrenia

This 2020 preclinical study investigated the effects of BPC 157, a stable gastric pentadecapeptide, on L-NAME-induced catalepsy in rat models mimicking 'positive-like' symptoms of schizophrenia. L-NAME, a nitric oxide synthase inhibitor, induces catalepsy by disrupting nitric oxide (NO) signaling, which is implicated in schizophrenia pathophysiology. The study found that BPC