Consumption of high-dose vitamin C (1250 mg per day) enhances functional and structural properties of serum lipoprotein to improve anti-oxidant, anti-atherosclerotic, and anti-aging effects via regulation of anti-inflammatory microRNA

This 2015 clinical study investigated the effects of daily high-dose vitamin C (1250 mg) supplementation over 8 weeks in 46 healthy young adults (including smokers). Results showed enhanced serum antioxidant activity, reduced advanced glycation end products and reactive oxygen species, and improved lipoprotein profiles. Specifically, apoB-48 in LDL disappeared, and