Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice

In this 2015 study, Hurez et al. investigated the effects of chronic mTOR inhibition via rapamycin on immune cell populations, gut microbiota, and lifespan in immune-deficient mice. The researchers administered rapamycin to mice and observed significant alterations in various immune cells, including T cells, B cells, myeloid cells, and innate