This literature review examines the adaptogenic properties of several plant-derived substances, including Eleutherococcus senticosus, Panax ginseng, Withania somnifera, and others, which have demonstrated stress-modulating, antioxidant, anti-fatigue, and performance-enhancing effects in animal models. The review also highlights phytochemicals such as ginsenosides, salidroside, and cucurbitacin R, noting their significant adaptogenic activities. Adaptogens